CLEOPATRA sheds light on how to tackle metastatic disease

PET sheds light on Alzheimer's disease genetic risk.

T wenty-plus years of positron emission tomography (PET) data show that relative to cognitively intact controls, persons with Alzheimer’s disease (AD) have reduced 2-[18F]fluoro-2-deoxy-D-glucose (FDG) uptake. This phenomenon is seen in brain regions containing amyloid plaques and neurofibrillary tangles, and supports the assertion that AD brains have reduced glucose consumption (1). From a dia...

Non-Linear Optical Microscopy Sheds Light on Cardiovascular Disease

Many cardiac diseases have been associated with increased fibrosis and changes in the organization of fibrillar collagen. The degree of fibrosis is routinely analyzed with invasive histological and immunohistochemical methods, giving a limited and qualitative understanding of the tissue's morphological adaptation to disease. Our aim is to quantitatively evaluate the increase in fibrosis by thre...

How to tackle a possible Creutzfeldt-Jakob disease necropsy.

How to tackle antimalarial resistance?

L ife has a prodigious capacity to overcome death, and this is exactly emblematic of drug resistance, one of the biggest threats for health systems, clinicians, researchers and patients. Several decades of intense and innovative drug discovery and development were not able to prevent the loss of medicines owing to resistance among viruses, bacteria and parasites. The common denominator to drug ...

The worm sheds light on anesthetic mechanisms

One hundred and sixty five years have passed since the first documented use of volatile anesthetics to aid in surgery, but we have yet to understand the underlying mechanism of action of these drugs. There is no question that, in vitro, volatile anesthetics can affect the function of numerous neuronal and non-neuronal proteins. In fact, volatile anesthetics are capable of binding such diverse p...